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Frequently Asked Questions

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“To be able to enjoy a meal and not have the discomfort is wonderful.” – T.S.

Celiac Disease and Gluten Sensitivity

What is the difference between Celiac Disease and gluten sensitivity?

Celiac disease patients have antibodies in their blood and an abnormal biopsy of the small bowel which can easily be confirmed by gastroenterologists. However, there are no blood tests or endoscopic signs for gluten sensitive patients.

What are the symptoms of gluten sensitivity?

Gastrointestinal:
– Nausea/vomiting
– Bloating/cramping
– Flatulence
– Abdominal pain
– Diarrhea
– Constipation

Extra-gastrointestinal:
– Fatigue/tiredness
– Weight loss
– Joint pains

Neurological:
– Headaches
– Concentration & memory problems (termed as gluten syndrome)

What causes gluten sensitivity?

At present, research suggests possible risk factors include human genetics, plant genetics, modification of gluten as food additives and environmental toxins.

If I have gluten sensitivity, will I eventually have Celiac Disease?

No. Scientific data does not prove that relationship.

How do you diagnose gluten sensitivity?

Tests are not available for gluten sensitivity. Usually, patients complain of symptoms such as gas, bloating, and abdominal cramping on introduction of gluten into their diet and elimination of gluten improves their symptoms.

Is there any medication available for Celiac Disease or gluten sensitivity?

Unfortunately, medication is not currently available for Celiac Disease. There is one clinical trial being conducted which combines various enzymes. The mainstay of the treatment today is to avoid gluten.

About ZyGluten™

What is ZyGluten™?

ZyGluten™ is a digestive supplement containing a mixture of gluten-breaking enzymes. It is derived from plant and microbial sources to help the digestion of gluten, proteins, carbohydrates, fats, and fiber. ZyGluten™ also contains helpful microbes which help in breaking down gluten.

Has there been any testing done for ZyGluten™?

Yes. ZyGluten™ was developed and tested in the lab by scientists, who specialize in enzymology and microbiology, and clinically tested by gastroenterologists on patients with symptoms of gluten sensitivity.

Do I need a prescription for ZyGluten™?

No. ZyGluten™ is available over-the-counter as a dietary supplement. No prescription is required.

Can ZyGluten™ be given to children?

ZyGluten™ has not been tested in children. You should consult your doctor or healthcare professional.

Can ZyGluten™ be given to pregnant or lactating mothers?

You should consult your doctor or healthcare professional before taking ZyGluten™ if you are pregnant or trying to get pregnant.

Can ZyGluten™ be given for Celiac Disease?

Trials have not been conducted for treatment of Celiac Disease with ZyGluten™. You should consult your doctor or healthcare professional with further questions.

Do ZyGluten™ capsules contain animal products?

No. ZyGluten™ capsules are suitable for vegetarians. They do not contain animal products.

Are there chemical ingredients in ZyGluten™?

ZyGluten™ is composed of enzymes from plant/microbial sources and helpful microbes, all of which are natural ingredients.

Will ZyGluten™ cross-react with other medications or antibiotics?

Research in this area has not been conducted. However, one should avoid taking ZyGluten™ with other medications simultaneously. You should consult your doctor or healthcare professional with further questions.

Taking ZyGluten™

How much ZyGluten™ should I take?

It is recommended that you take two capsules of ZyGluten™ immediately before your first bite of food, preferably twice per day with major meals.

When should I take ZyGluten™ capsules?

Take two ZyGluten™ capsules immediately before starting a meal. Take two more capsules if your meal lasts more than 30 minutes.

Who should not take ZyGluten™ capsules?

ZyGluten™ capsules are not recommended for children, or for women who are pregnant or nursing. You should consult a doctor before taking ZyGluten™ capsules if you are taking medication or have a medical condition.

Do I have to take ZyGluten™ capsules with EVERY meal?

Due to hidden gluten in many foods, it is best to take ZyGluten™ capsules with every meal. However, the ultimate decision of when to take ZyGluten™ capsules is up to you.

Can I take ZyGluten™ capsules after a meal if I forget to take them before a meal?

For maximum benefit, ZyGluten™ capsules must be taken before or during a meal.

Can I chew ZyGluten™ capsules or sprinkle their contents on food?

No. ZyGluten™ capsules should be taken orally with water immediately before a meal.

Can I take ZyGluten™ capsules in conjunction with alcoholic beverages?

Do not swallow ZyGluten™ capsules with alcohol prior to a meal on an empty stomach. You may drink alcohol once ZyGluten™ capsules and food have been consumed.

Can I skip ZyGluten™ on certain days?

If you do not have gluten in your diet and you avoid all items containing “hidden” gluten, you may skip taking ZyGluten™. However, it is generally very difficult to determine if food contains gluten, particularly when eating out.

Can I stop ZyGluten™ abruptly?

It is possible that your symptoms of gluten sensitivity will return, but ZyGluten™ does not have to be tapered down. The ultimate decision regarding your healthcare needs should be made between you and your doctor after weighing the risks and benefits.

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“My experience with ZyGluten™ has been simply amazing. It has made my quality of life so much better.” – C.M.

References
1.) Journal of Gluten Sensitivity. 2015 Jan; 14(1):17-21. Evaluation of Safety and Efficacy of Dietary Supplement ZyGluten In Patients with Gluten Sensitivity.
Narula, AP.

2.) Am J Gastroenterol. 2011 Mar;106(3):508-14; quiz 515. doi: 10.1038/ajg.2010.487. Epub 2011 Jan 11. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial.
Biesiekierski JR1, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD, Shepherd SJ, Muir JG, Gibson PR.

3.) The Oslo definitions for celiac disease and related terms.
Jonas F Ludvigsson,1,2 Daniel A Leffler,3 Julio C Bai,4 Federico Biagi,5 Alessio Fasano,6
Peter H R Green,7 Marios Hadjivassiliou,8 Katri Kaukinen,9 Ciaran P Kelly,3
Jonathan N Leonard,10 Knut Erik Aslaksen Lundin,11 Joseph A Murray,12
David S Sanders,13,14 Marjorie M Walker,14 Fabiana Zingone,15 Carolina Ciacci16

4.) Food Allergy – An Overview (PDF|1 MB). DHHS. NIH. National Institute of Allergy and Infectious Diseases.

5.) Gastroenterol Hepatol. 2014 Jun-Jul;37(6):362-71. doi: 10.1016/j.gastrohep.2014.01.005. Epub 2014 Mar 22. [Non-celiac gluten sensitivity: a critical review of current evidence].
[Article in Spanish]
Molina-Infante J1, Santolaria S2, Montoro M2, Esteve M3, Fernández-Bañares F3.

6.) Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease: A Double-Blind Randomized Placebo-Controlled Trial.
Jessica R Biesiekierski, Evan D Newnham, Peter M Irving, Jacqueline S Barrett, Melissa Haines, James D Doecke, Susan J Shepherd, Jane G Muir and Peter R Gibson

7.) Nutrients. 2013 Sep 26;5(10):3839-53. doi: 10.3390/nu5103839. Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders.
Catassi C1, Bai JC, Bonaz B, Bouma G, Calabrò A, Carroccio A, Castillejo G, Ciacci C, Cristofori F, Dolinsek J, Francavilla R, Elli L, Green P, Holtmeier W, Koehler P, Koletzko S, Meinhold C, Sanders D, Schumann M, Schuppan D, Ullrich R, Vécsei A, Volta U, Zevallos V, Sapone A, Fasano A.

8.) BMC Med. 2014 May 23;12:86. doi: 10.1186/1741-7015-12-86.
Non-celiac gluten sensitivity – why worry?
Lundin KE.

9.) BMC Med. 2014 May 23;12:85. doi: 10.1186/1741-7015-12-85.
An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity.
Volta U1, Bardella MT, Calabrò

10.) Neurogastroenterol Motil. 2013 Nov;25(11):864-71. doi: 10.1111/nmo.12216. Epub 2013 Aug 12. Non-celiac gluten sensitivity: clinical relevance and recommendations for future research.
Mooney PD1, Aziz I, Sanders DS.

11.) World J Gastroenterol. 2014 Jul 21;20(27):8837-45. doi: 10.3748/wjg.v20.i27.8837.
Irritable bowel syndrome and food interaction.
Cuomo R, Andreozzi P, Zito FP, Passananti V, De Carlo G, Sarnelli G.

12.) Expert Rev Gastroenterol Hepatol. 2012;6(1):43-55. Problems of an Emerging Condition Separate From Celiac Disease.
Amy C Brown

13.) Dig Dis Sci. 1999 Jul;44(7):1317-21. Pancreatic supplements reduce symptomatic response of healthy subjects to a high fat meal.
Suarez F1, Levitt MD, Adshead J, Barkin JS.

DISCLAIMER: ZyGluten™ capsules are intended for adults only. Consult your doctor before taking this product if you have a medical condition or are taking any medication. Consult your doctor if symptoms continue or worsen. Do not take if you are pregnant or nursing. Take two capsules immediately before consuming foods containing gluten. Store in a cool, dry place with cap tightly closed. Do not freeze.